Spectrin beta III Antibody / SPTBN2
Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Spectrin alpha and spectrin beta are present in erythrocytes, whereas spectrin alpha II (fodrin a) and spectrin beta I (fodrin b) are present in other somatic cells. SPTBN2/Spectrin beta III is highly homologous to both spectrin beta I and spectrin beta II. SPTBN2 is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta.
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
O15020
Host
Mouse
Reactivity
Human
Immunogen
Human recombinant partial protein corresponding to amino acids 356-475 was used as the immunogen for this Spectrin beta III antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
SPTBN2/1583
Applications
FACS, IF, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Spectrin beta III antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Spectrin beta III antibody is available for research use only.
Storage Conditions
Store the Spectrin beta III antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Location
Cell surface, cytoplasm
Image Legend
Immunofluorescent staining of MeOH fixed human HeLa cells with Spectrin beta III antibody (clone SPTBN2/1583, green) and Reddot nuclear stain (red) .
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