PTH Antibody / N-Terminal
PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH) ; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
Product Specifications
Specifications
Immunohistochemistry (FFPE) : 0.5-1 µg/mL for 30 min at RT
UniProt
P01270
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide from the N-terminal region of human Parathyroid hormone was used as the immunogen for the PTH antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the PTH antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PTH antibody is available for research use only.
Storage Conditions
Store the PTH antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Product Datasheet
https://www.nsjbio.com/tds-pdf/pth-antibody-n-terminal-v3375
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the PTH antibody should be determined by the researcher.
CAS Number
9007-83-4
Location
Cytoplasmic and secreted
Image Legend
IHC testing of FFPE human parathyroid gland stained with PTH antibody. Required HIER: steam sections in 10mM citrate buffer, pH 6.0, for 10-20 min.
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