LHR Antibody / hCG Receptor

Recognizes a protein of 78-85 kDa, which is identified as the receptor for Luteinizing hormone / Choriogonadotropin (LHR/CGR) . Luteinizing hormone plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Choriogonadotropin production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone / choriogonadotropin receptor (LHCGR) as a seven transmembrane, G protein-coupled receptor glycoprotein. LHCGR influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of LHCGR on breast carcinoma correlates in part to the degree of tumor differentiation. LHCGR -positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women.

Product Specifications

CAS Number

9007-83-4

Specifications

ELISA (order BSA/sodium azide-free format for coating), Flow cytometry: 1-2ug/10^6 cells, Western blot: 0.5-1 µg/mL

UniProt

P22888

Host

Mouse

Reactivity

Human

Immunogen

A partial recombinant protein from the N-terminal region of human Luteinizing hormone / Choriogonadotropin receptor was used as the immunogen for the LHR antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

LHCGR/1417

Applications

ELISA, FACS, WB

Purity

Protein G affinity chromatography

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Reconstitution

Store the LHR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This LHR antibody is available for research use only.

Storage Conditions

Store the LHR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Applications Notes

Optimal dilution of the LHR antibody should be determined by the researcher.

Location

Cytoplasmic, cell surface

Image Legend

IHC testing of FFPE human ovarian carcinoma with LHR antibody (clone LHCGR/1417) . Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min.