TL1A Antibody / TNFSF15 / VEGI

TNF ligand-related molecule 1 is an anti-angiogenic cytokine that is also called Tumor necrosis factor superfamily, member 15 (TNFSF15) and Vascular endothelial growth inhibitor (VEGI/VEGI192A) . This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of TL1A has been reported as a marker of poor prognosis in breast cancer.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT

UniProt

O95150

Host

Mouse

Reactivity

Human

Immunogen

A full length human recombinant protein was used as the immunogen for this TL1A antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

VEGI/1283

Applications

IHC-P

Purity

Protein G affinity chromatography

Format

Purified

Buffer

1X PBS, pH 7.4

Reconstitution

Store the TL1A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This TL1A antibody is available for research use only.

Storage Conditions

Store the TL1A antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

Titration of the TL1A antibody may be required for optimal performance.

Location

Cytoplasmic, cell surface, secreted

Image Legend

IHC testing of FFPE human colon carcinoma with TL1A antibody (clone VEGI/1283) . Required HIER: boil sections in 10mM Tris with 1mM EDTA, pH9, for 10-20 min followed by cooling at RT for 20 min.