GP2 Antibody / Glycoprotein 2 / ZAP75
GP2 (Glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD) . GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA: 2-4 µg/mL (order BSA/azide-free format), Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P55259
Host
Mouse
Reactivity
Human
Immunogen
A partial human recombinant protein corresponding to amino acids 35-179 was used as the immunogen for the GP2 antibody.
Clonality
Monoclonal
Isotype
IgG2b λ
Clone
GP2/1712
Applications
ELISA, IHC-P, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the GP2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This GP2 antibody is available for research use only.
Storage Conditions
Store the GP2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the GP2 antibody should be determined by the researcher.
Location
Cytoplasmic, membranous, secreted
Image Legend
IHC testing of FFPE human pancreas with GP2 antibody (clone GP2/1712) . HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min.
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