Dendrotoxin K
Dendrotoxin K is a Kv1.1 channel blocker. Dendrotoxin K determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform[1].
Product Specifications
CAS Number
119128-61-9
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dendrotoxin-k.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](C(C)C)C(NCC(O)=O)=O)=O)NC2=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(NCC(N4[C@@H](CCC4)C(N[C@@H](CSSC[C@@H](C(NCC(NCC(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@H]6CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC7=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N8[C@@H](CCC8)C(N[C@@H](CO)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H](CC%10=CC=C(C=C%10)O)C(N[C@@H](CC%11=CC=C(C=C%11)O)C(N[C@@H](CCCCN)C(N[C@@H](CC%12=CNC%13=CC=CC=C%12%13)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H]2[C@H](O)C)=O)=O)=O)NC6=O)C(N[C@@H](CC(C)C)C(N%14[C@@H](CCC%14)C(N[C@@H](CC%15=CC=CC=C%15)C(N[C@@H](CC(O)=O)C(N[C@@H](CC%16=CC=C(C=C%16)O)C(N[C@@H](CO)C(NC7)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Molecular Formula
C294H456N84O75S6
Molecular Weight
6559.66
References & Citations
[1]Bialowas A, et al. Analog modulation of spike-evoked transmission in CA3 circuits is determined by axonal Kv1.1 channels in a time-dependent manner. Eur J Neurosci. 2015 Feb;41 (3) :293-304.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
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