Connexin 32 Antibody / GJB1
This Ab recognizes a protein of 27-32 kDa, identified as Connexin 32. The connexin family of proteins forms hexameric complexes called connexons that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane α-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino-acid substitutions in the most highly conserved domains, the transmembrane and extracellular regions. Each of the approximately 20-connexin isoforms produces channels with distinct permeability and electrical and chemical sensitivities; therefore, one connexin usually cannot fully substitute for another.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA: 1-5 µg/mL for coating (order BSA/sodium azide-free format)
UniProt
P28230
Host
Rat
Reactivity
Mouse, Rat
Immunogen
Mouse liver DOC-JR-plasma membranes were used as the immunogen for the Connexin 32 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
R5.21C
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Connexin 32 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Connexin 32 antibody is available for research use only.
Storage Conditions
Store the Connexin 32 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Connexin 32 antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
SDS-PAGE Analysis of Purified, BSA-Free Connexin 32 Antibody (clone R5.21C) . Confirmation of Integrity and Purity of the Antibody.
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