Integrin beta 3 Antibody / CD61 / ITGB3
Reacts with human Integrin beta 3, also called CD61. It associates with the αV-chain (CD51) to form vitronectin receptor, or with the αIIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61) . The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (Frozen & FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P05106
Host
Mouse
Reactivity
Human
Immunogen
Human recombinant protein used as the immunogen for the Integrin beta 3 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
ITGB3/1713
Applications
IHC-P
Purity
Protein G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Integrin beta 3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Integrin beta 3 antibody is available for research use only.
Storage Conditions
Store the Integrin beta 3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Titration of the Integrin beta 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cell surface, cytoplasmic
Image Legend
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