Alpha-1-Antichymotrypsin Antibody / AACT / SERPINA3

Alpha 1-Antichymotrypsin, also called AACT and SERPINA3, inhibits the activity of certain proteases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes. This protein is produced in the liver, and is an acute phase protein that is induced during inflammation. [Wiki]

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT

UniProt

P01011

Host

Mouse

Reactivity

Human

Immunogen

A human partial recombinant protein was used as the immunogen for this Alpha-1-Antichymotrypsin antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

AACT/1452

Applications

IHC-P

Purity

Protein G affinity

Format

Purified

Buffer

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution

Store the Alpha-1-Antichymotrypsin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This Alpha-1-Antichymotrypsin antibody is available for research use only.

Storage Conditions

Store the Alpha-1-Antichymotrypsin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

The stated application concentrations are suggested starting amounts. Titration of the Alpha-1-Antichymotrypsin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Location

Cytoplasmic

Image Legend

IHC testing of FFPE human pancreas with Alpha-1-Antichymotrypsin antibody (clone AACT/1452) . Required HIER: steam sections in pH6, 10mM citrate buffer for 10-20 min.