FKK6
FKK6 is a selective agonist for pregnane X receptor (PXR) with an EC50 of 1.2 µM. FKK6 exhibits good affinity with plasma proteins, and good metabolic metabolism in human microsomes. FKK6 inhibits PXR-related NF-κB signaling pathway, inhibits the expression of inflammatory factors, and exhibits anti-inflammatory activity against DSS -induced colitis in mouse model[1][2].
Product Specifications
CAS Number
2238839-34-2
UNSPSC
12352005
Target
Interleukin Related; NF-κB
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fkk6.html
Purity
99.14
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C#CCC(O)(C1=CC=NC=C1)C2=CC3=CC=CC=C3N2S(=O)(C4=CC=CC=C4)=O
Molecular Formula
C23H18N2O3S
Molecular Weight
402.47
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Human IgG Immunoglobulin (IG266), CF568 conjugate, 0.1mg/mL
CD81 / TAPA-1 (1.3.3.22), CF647 conjugate, 0.1mg/mL
CD31 / PECAM-1 (158-2B3), CF405S conjugate, 0.1mg/mL
