FKK6

FKK6 is a selective agonist for pregnane X receptor (PXR) with an EC50 of 1.2 µM. FKK6 exhibits good affinity with plasma proteins, and good metabolic metabolism in human microsomes. FKK6 inhibits PXR-related NF-κB signaling pathway, inhibits the expression of inflammatory factors, and exhibits anti-inflammatory activity against DSS (HY-116282) -induced colitis in mouse model[1][2].

Product Specifications

CAS Number

[2238839-34-2]

UNSPSC

12352005

Target

Interleukin Related; NF-κB

Type

Reference compound

Related Pathways

Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fkk6.html

Purity

99.14

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C#CCC(O)(C1=CC=NC=C1)C2=CC3=CC=CC=C3N2S(=O)(C4=CC=CC=C4)=O

Molecular Formula

C23H18N2O3S

Molecular Weight

402.47

References & Citations

[1]Dvořák Z, et al., In vitro safety signals for potential clinical development of the anti-inflammatory pregnane X receptor agonist FKK6. Bioorg Chem. 2024 Mar;144:107137.|[2]Dvořák Z, et al., Targeting the pregnane X receptor using microbial metabolite mimicry. EMBO Mol Med. 2020 Apr 7;12 (4) :e11621.