Plakoglobin Antibody / Gamma Catenin
It recognizes a protein of 80-87kDa, identified as gamma-Catenin or Plakoglobin. The catenins (α, β, γ and δ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. α T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. α T-catenin binds to α E-catenin as well as to β-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for α-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.
Product Specifications
Specifications
Immunofluorescence: 1-2 µg/mL, Western blot: 0.5-1 µg/mL, Flow cytometry: 1-2ug/10^6 cells
UniProt
P14923
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Clonality
Monoclonal
Isotype
IgG1 k
Clone
11E4.
Applications
IF, WB, FACS
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Plakoglobin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Plakoglobin antibody is available for research use only.
Storage Conditions
Store the Plakoglobin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Product Datasheet
https://www.nsjbio.com/tds-pdf/plakoglobin-antibody-gamma-catenin-11e4-v3204
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Titration of the Plakoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
CAS Number
9007-83-4
Location
Cell surface, cytoplasmic, cell junctions
Image Legend
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