Galectin 1 Antibody
Galectin 1 is a member of the beta-galactoside-binding family and is a dimeric protein of 14 kDa participating in a variety of normal and pathological processes, including cancer progression. Galectin 1 can affect the proliferation of normal and malignant cells. Inhibition of cell growth is observed in a lactose-dependent manner as lower concentrations of the lectin stimulate cell proliferation. Galectin 1 may also be implicated in the induction of apoptosis of activated T cells through the binding of exogenous galectin-1 to CD45 molecules present on the surface of lymphocytes. Galectin 1, reported to be present either at the surface of cancer cells or accumulated around these cells could act as an immunological shield to protect against a T cell immune response and provide an advantage for survival.
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
P09382
Host
Mouse
Reactivity
Human
Immunogen
A human partial recombinant protein corresponding to amino acids 12-108 was used as the immunogen for the Galectin 1 antibody.
Clonality
Monoclonal
Isotype
IgG1 λ
Clone
GAL1/1831
Applications
ELISA, IF, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Galectin 1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Galectin 1 antibody is available for research use only.
Storage Conditions
Store the Galectin 1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Titering of the Galectin 1 antibody may be required for optimal performance.
Location
Cytoplasmic, secreted
Image Legend
Western blot testing of human 1) JEG-3 and 2) K562 cell lysate with Galectin 1 antibody (clone GAL1/1831) . Expected molecular weight ~14 kDa.
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