TRP1 Antibody / Tyrosinase-Related Protein-1 Antibody / TYRP1
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1) . It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10^6 cells, Immunofluorescence: 1-2 µg/mL
UniProt
P17643
Host
Mouse
Reactivity
Human, Mouse
Immunogen
SK-MEL-23 cells were used as the immunogen for this TRP1 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
TA99
Applications
FACS, IF
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the TRP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This TRP1 antibody is available for research use only.
Storage Conditions
Store the TRP1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
The optimal dilution of the TRP1 antibody for each application should be determined by the researcher.
Location
Cytoplasmic
Image Legend
SDS-PAGE analysis of purified, BSA-free TRP1 antibody (clone TA99) as confirmation of integrity and purity.
Frequently Asked Questions
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