MUC1 Antibody Cocktail
In Western blotting, it recognizes proteins in MW range of 265-400kDa, identified as different glycoforms of EMA. The alpha subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinoma tissues. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
P15941
Host
Mouse
Reactivity
Human
Immunogen
Human milk fat globule membranes were used as the immunogen for this MUC1 antibody.
Clonality
Monoclonal
Isotype
IgG1,IgG2a
Clone
GP1.4 + E29
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the MUC1 antibody cocktail at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This MUC1 antibody cocktail is available for research use only.
Storage Conditions
Store the MUC1 antibody cocktail at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic & cell surface
Image Legend
IHC: Formalin-fixed, paraffin-embedded human colon carcinoma stained with MUC-1 / EMA antibody cocktail (clones GP1.4 + E29) .
Documents
Frequently Asked Questions
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