Macrophage / Histiocytoma Marker Antibody
In Western blotting, it detects an antigen of 125kDa in human liver and 135kDa in tumors of histiocytic origin. Comparative study of this mAb and a standard CD68 mAb showed that their antigens are different. Its antigen in all macrophage types studied is located on the plasma membrane and within cytoplasmic structures including lysosomes. This mAb shows a restricted reactivity to cells of the monocyte/macrophage system. It specifically reacts with blood monocytes and stains resident macrophages in a wide variety of human tissues. This mAb does not stain antigen-presenting cells, e.g., Langerhans cells. Reportedly, its reactivity is restricted to histiocytes and macrophages.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.5-1 µg/mL for 30 min at RT
UniProt
Not Known
Host
Mouse
Reactivity
Human, Rat
Immunogen
A membrane preparation from human hepatocytes was used as the immunogen for the Macrophage / Histiocytoma Marker antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
D11
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Macrophage / Histiocytoma Marker antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Macrophage / Histiocytoma Marker antibody is available for research use only.
Storage Conditions
Store the Macrophage / Histiocytoma Marker antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cell surface & cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human Histiocytoma stained with Macrophage antibody (D11) .
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