CD59 Antibody
Reacts with human CD59, a 20kDa glycosyl phosphatidyl-inositol (GPI) -anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH) . It is useful for study on GPI-anchored proteins, PNH and CD59 functions.
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
P13987
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the CD59 antibody.
Clonality
Monoclonal
Isotype
IgM k
Clone
MACIF/1193
Applications
IHC-P
Purity
PEG precipitation
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the CD59 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD59 antibody is available for research use only.
Storage Conditions
Store the CD59 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Plasma membrane, cytoplasm
Image Legend
IHC: Formalin-fixed, paraffin-embedded human tongue stained with CD59 antibody (MACIF/1193)
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