Carbonic Anhydrase 9 Antibody
Recognizes a glycoprotein identified as carbonic anhydrase IX (CAIX/CA9) . Its epitope resides in the carbohydrate domain of CA9. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, CA9 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, CA9 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This mAb may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
Q16790
Host
Mouse
Reactivity
Human
Immunogen
The microsomal fraction of human renal cortical tissue homogenate was used as the immunogen for the Carbonic Anhydrase 9 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
PN-15
Applications
FACS, IF, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Carbonic Anhydrase 9 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Carbonic Anhydrase 9 antibody is available for research use only.
Storage Conditions
Store the Carbonic Anhydrase 9 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cell surface and cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with Carbonic Anhydrase 9 antibody (PN-15) .
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