Gp96 Antibody / GRP94 / HSP90B1
Recognizes a protein of 94kDa, which is identified as the glucose-regulated protein 94 (grp94) and also tumor rejection antigen (gp96) . Gp96 shows a high degree of sequence homology with the heat shock protein 90 (hsp90) . This mAb is highly specific and shows minimal cross-reaction with other members of the HSP90 family. Grps are a class of proteins unresponsive to heat shock and are induced by glucose deprivation. Gp96 has been briefly studied as a prognostic factor in breast cancer.
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
P14625
Host
Rat
Reactivity
Human
Immunogen
Purified glucose regulated protein 94 from chicken oviducts was used as the immunogen for the gp96 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
SPM249
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the gp96 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This gp96 antibody is available for research use only.
Storage Conditions
Store the gp96 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic and nuclear
Image Legend
IHC analysis of formalin-fixed, paraffin-embedded human breast carcinoma stained with gp96 antibody (SPM249) .
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