TGF-beta Antibody (1/2/3)
This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80% identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
P01137, P10600, P61812
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Bovine TGF-beta2 protein was used as the immunogen for the TGF-beta antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1D11.16.8
Applications
Cytokine neutralization, Functional assay, ELISA, IF, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the TGF-beta antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This TGF-beta antibody is available for research use only.
Storage Conditions
Store the TGF-beta antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the TGF-beta antibody should be determined by the researcher.
Location
Cytoplasm and extracellular (secreted)
Frequently Asked Questions
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