PECAM Antibody PE Conjugate
CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 mAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow Cytometry: 5ul per test per one million cells in 0.1ml
UniProt
P16284
Host
Mouse
Reactivity
Human
Immunogen
Membrane preparation of a spleen from a patient with hairy cell leukemia was used as the immunogen for the PECAM antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM122
Applications
FACS
Purity
Protein G affinity chromatography
Format
PE Conjugate
Buffer
500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the PECAM antibody at 2-8oC. Conjugate is light sensitive, store in the dark.
Limitations
This PECAM antibody is available for research use only.
Storage Conditions
Store the PECAM antibody at 2-8°C. Conjugate is light sensitive, store in the dark.
Formulation
500 ul at 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the PECAM antibody should be determined by the researcher.
Location
Cell surface and cytoplasm of endothelial cells
Image Legend
Flow Cytometry testing of Jurkat cells. Black: cells alone; Green: isotype control; Red: PE-labeled PECAM antibody (SPM122) .
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