Ornithine Decarboxylase Antibody
Recognizes a 53kDa protein, identified as the Ornithine Decarboxylase (ODC-1) . ODC is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC-1 is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.
Product Specifications
CAS Number
9007-83-4
Specifications
UniProt
P11926
Host
Mouse
Reactivity
Human, Rat
Immunogen
Recombinant human protein was used as the immunogen for the Ornithine Decarboxylase antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
ODC1/487
Applications
FACS, IF, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Ornithine Decarboxylase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Ornithine Decarboxylase antibody is available for research use only.
Storage Conditions
Store the Ornithine Decarboxylase antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic
Image Legend
IF staining of LNCap cells using AF488 labeled Ornithine Decarboxylase antibody (ODC1/487) (Green) . DAPI was used to stain the cell nuclei (blue) .
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