NK-252

NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential.

Product Specifications

CAS Number

[1414963-82-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Keap1-Nrf2; Quinone Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NK-252.html

Purity

99.60

Solubility

DMSO : ≥ 29 mg/mL

Smiles

O=C(NCC1=NC=CC=C1)NC2=NN=C(C3=CC=CO3)O2

Molecular Formula

C13H11N5O3

Molecular Weight

285.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Shimozono R et al. Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol Pharmacol. 2013 Jul, 84 (1) :62-70.|[2]Kiue A, et al. Enhancement of antitumour activity of etoposide by dihydropyridines on drug-sensitive and drug-resistant leukaemia in mice. Br J Cancer. 1991 Aug;64 (2) :221-6.