CD11c Antibody
Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs) . A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA: 2-4 µg/mL (order BSA/azide-free format)
UniProt
P20702
Host
Mouse
Reactivity
Human
Immunogen
A partial recombinant protein corresponding to amino acids 637-827 from human ITGAX/CD11c was used as the immunogen for the CD11c antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
ITGAX/1243
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CD11c antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD11c antibody is available for research use only.
Storage Conditions
Store the CD11c antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CD11c antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
Note staining of cancer cells.
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