CD11a Antibody / LFA-1
Recognizes a protein of 180 kDa, identified as CD11a (Leucocyte Workshop IV; Code 1524) . CD11a complex with the beta 2 subunit of the integrin family, CD18, to form the cell surface heterodimer, LFA-1 or CD11a /C18 (aLbL) . LFA-1 is expressed on all leukocytes including lymphocytes, monocytes, and granulocytes. It is involved in leukocyte adhesion to its ligands including intercellular adhesion molecule-1 (ICAM-1 or CD54), ICAM-2 (CD102), ICAM-3 (CD50) and Telencephalin (TLN) and play a role in most immune/inflammatory responses. This mAb potently blocks LFA-1 dependent homotypic cell aggregation.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10^6 cells, Immunofluorescence: 1-2 µg/mL, Functional studies (order BSA/sodium azide-free format)
UniProt
P20701
Host
Mouse
Reactivity
Human
Immunogen
Human CD11a protein was used as the immunogen for the CD11a antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
DF1524
Applications
FACS, IF, Functional studies
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CD11a antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD11a antibody is available for research use only.
Storage Conditions
Store the CD11a antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CD11a antibody should be determined by the researcher.
Location
Cell surface
Image Legend
SDS-PAGE Analysis of Purified, BSA-Free CD11a Antibody (clone DF1524) . Confirmation of Integrity and Purity of the Antibody.
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