Anti-HSP60 Antibody / HSPD1
Recognizes a 60kDa protein, identified as the heat shock protein 60 (Hsp60) . Its epitope is localized between amino acids 383-447 of human Hsp60. A wide variety of environmental and pathophysiological stressful conditions trigger the synthesis of a family of proteins known as heat shock proteins (hsps), more appropriately called as stress response proteins (srps) . Hsp60 is a potential antigen in a number of autoimmune diseases. In human arthritis and in experimentally induced arthritis in animals, disease development coincides with the development of immune reactivity directed against not only bacterial Hsp60, but also against its mammalian homolog.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1-2 µg/mL, Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P10809
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for the anti-HSP60 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM253
Applications
IF, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the anti-HSP60 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This anti-HSP60 antibody is available for research use only.
Storage Conditions
Store the anti-HSP60 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasm (mitochondria)
Image Legend
Formalin-fixed, paraffin-embedded human bladder carcinoma stained with anti-HSP60 antibody (clone SPM253) .
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