HLA-DR Antibody (HLA-DP)
Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DR and DP. Human MHC class II antigens are transmembrane glycoproteins composed of an chain (36kDa) and a chain (27kDa) . They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.
Product Specifications
Specifications
Flow cytometry: 1-2ug/10^6 cells, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P04440, P01903
Host
Mouse
Reactivity
Human
Immunogen
Human REH cells were used as the immunogen for the HLA-DR antibody (HLA-DP) .
Clonality
Monoclonal
Isotype
IgG3 κ
Clone
Bra-14
Applications
FACS, IF, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the HLA-DR antibody (HLA-DP) at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This HLA-DR antibody (HLA-DP) is available for research use only.
Storage Conditions
Store the HLA-DR antibody (HLA-DP) at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Product Datasheet
https://www.nsjbio.com/tds-pdf/hla-dr-antibody-hla-dp-bra-14-v2580
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
CAS Number
9007-83-4
Location
Cell surface
Image Legend
IHC: Formalin-fixed, paraffin-embedded human tonsil stained with HLA-DP / HLA-DR antibody (Bra-14) .
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