TRIM29 Antibody
It recognizes a 66kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29) . It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA: order BSA/sodium azide-free format for coating, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q14134
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment (126 amino acid residues between aa 1-200) of human TRIM29 protein was used as the immunogen for the TRIM29 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
TRIM29/1041
Applications
ELISA, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the TRIM29 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This TRIM29 antibody is available for research use only.
Storage Conditions
Store the TRIM29 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic & cell surface
Image Legend
IHC: Formalin-fixed, paraffin-embedded human lung squamous cell carcinoma stained with TRIM29 antibody (clone TRIM29/1041) .
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