Anti-CD8 Antibody (alpha)
Cluster of Differentiation 8 is a cell surface receptor expressed either as a heterodimer with the beta chain or as a homodimer. A majority of thymocytes and a subpopulation of mature Tcells and NK cells express CD8a. It binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in Tcell development and activation of mature Tcells. For mature Tcells, CD4 and 8 are mutually exclusive, so antibody to CD8 is generally used in conjunction with antibody to CD4.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA (order BSA/sodium azide-free format for coating), Flow cytometry: 0.5-1ug/million cells
UniProt
P01732
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human CD8a protein was used as immunogen for this anti-CD8 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
C8/1035
Applications
ELISA, FACS
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the anti-CD8 antibody (with azide) at 2-8oC. The azide-free format should be aliquoted and stored at -20oC or colder.
Limitations
This anti-CD8 antibody is available for research use only.
Storage Conditions
Store the anti-CD8 antibody (with azide) at 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Location
Cell surface
Image Legend
Flow cytometry staining of lymphocyte-gated human PBM cells with CD8 antibody (clone C8/1035) ; Gray=unstained, Red= CD8 antibody.
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