CD4 Antibody
CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA (order BSA/sodium azide-free format for coating), Flow cytometry: 1-2ug/million cells
UniProt
P01730
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human CD4 protein was used as immunogen for the CD4 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
C4/206
Applications
ELISA, FACS
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
CD4 antibody with azide can be stored at 2-8oC. The azide-free format should be aliquoted and stored at -20oC or colder.
Limitations
The CD4 antibody is available for research use only.
Storage Conditions
CD4 antibody with azide can be stored at 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CD4 antibody for a specific application should be determined by researcher.
Location
Cell surface
Image Legend
Flow cytometry staining of lymphocyte gated human PBM cells with CD4 antibody; Gray=unstained, Green= CD4 antibody.
Documents
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