HCG-beta Antibody
This antibody reacts with a protein of 22kDa, identified as beta subunit of HCG. It does not cross react with the alpha subunit. HCG is a glycoprotein which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and beta subunits. The alpha subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH) . HCG-beta antibody detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate antibody positivity in 90% and 60% of cases respectively; 20% of lung squamous cell carcinomas are positive. HCG expression by non-trophoblastic tumors may indicate aggressive behavior.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.5-1 µg/mL
Host
Mouse
Reactivity
Human
Immunogen
Recombinant protein was used as the immunogen for this HCG-beta antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
HCGb/459
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the HCG-beta antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This HCG-beta antibody is available for research use only.
Storage Conditions
Store the HCG-beta antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
HCGb/211HCGb/54
Location
Cytoplasmic, Secreted
Image Legend
Immunohistochemical testing of human placenta with HCG-beta antibody (HCGb/459) .
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