EBV Early Antigens Antibody

Epstein-Barr virus (EBV), also designated human herpesvirus 4 (HHV-4), is a member of the herpesvirus family and is one of the most common human viruses. EBV infects B cells and, though often asymptomatic, it can cause infectious mononucleosis, a disease characterized by fatigue, fever, sore throat and muscle soreness. The EBV-induced early antigens (Ea) are among several antigen complexes that have been identified in EBV-infected cells. The Ea complex is composed of diffuse (EaD) and restricted (EaR) components. The activity of EaD is suppressed during latent infection. BMRF1, the gene that encodes for EaD, is closely associated with the gene encoding for EBV DNA polymerase, and EaD is essential for the activity of this polymerase. EaD forms a complex with EBV DNase and, together, they may play a role in viral replication.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunofluorescence: 0.5-1 µg/mL

Host

Mouse

Reactivity

Epstein-Barr Virus

Immunogen

Affinity purified early antigen polypeptides from induced Raji cells precipitated with African Burkitt's lymphoma sera were used as the immunogen for this Early Antigens antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

1108-1

Applications

Purity

Protein G purified antibody

Format

Purified

Buffer

1X PBS, pH 7.4

Reconstitution

Store the EBV Early Antigens antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This EBV Early Antigens antibody is available for research use only.

Storage Conditions

Store the EBV Early Antigens antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Applications Notes

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the Early Antigens antibody to be titered up or down for optimal performance.