PLGF Antibody / PGF / Placenta Growth Factor

The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include fibroblast-, platelet derived-, vascular endothelial- and placenta- growth factor (PLGF) . Like vascular endothelial growth factor, several PLGF variants have been shown to arise from alternative mRNA splicings. Evidence has suggested VEGF to be an obligatory component in PLGF signaling. While VEGF homodimers and VEGF/PLGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PLGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PLGF. VEGF and PLGF share a common receptor, Flt-1, and may also activate Flk-1/KDR.

Product Specifications

CAS Number

9007-83-4

Specifications

ELISA (order BSA/sodium azide-free format for coating), Functional studies (order BSA/sodium azide-free format)

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human protein was used as the immunogen for this PLGF antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

PLGF94

Applications

ELISA, Functional studies

Purity

Protein G purified PLGF antibody

Format

Purified

Buffer

1X PBS, pH 7.4

Reconstitution

Store the PLGF antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This PLGF antibody is available for research use only.

Storage Conditions

Store the PLGF antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the PLGF antibody to be titered up or down for optimal performance.