MUC2 Antibody / Mucin-2
This antibody recognizes a single glycoprotein of 520kDa, identified as MUC2 (Mucin-2) . The MUC2 antibody shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC3. Mucins are high molecular weight glycoproteins, which constitute the major component of the mucus layer that protects the gastric epithelium. MUC2 is specifically expressed in goblet cells of the small intestine and colon; in about 65% of colonic carcinomas and about 40% of gastric carcinomas. MUC2 is rarely expressed outside of the GI tract with the exceptions of mucinous carcinoma of breast and clear cell-type carcinomas of the ovary.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.5-1 µg/mL for 30 min at RT (1), Prediluted IHC only format: incubate for 30 min at RT (2)
Host
Mouse
Reactivity
Human
Immunogen
Amino acids, KYPTTTPISTTTMVTPTPTPTGTQTPTTT, from human MUC2 / Mucin-2 protein, were used as the immunogen for this antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CCP58
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the MUC52 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This MUC2 antibody is available for research use only.
Storage Conditions
Store the MUC52 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic and cell surface
Image Legend
Formalin/paraffin normal human intestine stained with MUC2 antibody (CCP58) .
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