MUC18 Antibody / CD146
The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MUC18 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. MUC18 / CD146 is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 0.5-1ug/10^6 cells, Immunofluorescence: 0.5-1 µg/mL
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for this MUC18 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
OJ79c
Applications
FACS, IF
Purity
Protein G purified antibody
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the MUC18 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This MUC18 antibody is available for research use only.
Storage Conditions
Store the MUC18 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Location
Cell surface, cytoplasm
Image Legend
SDS-PAGE analysis of purified, BSA-free MUC18 antibody (clone OJ79c) as confirmation of integrity and purity.
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