Ku70 + Ku80 Antibody
Recognizes a dimer of two proteins of 70kDa and ~80kDa, identified as two subunits of Ku. MAb KU729 recognizes a conformational epitope of p70/p80 dimer, which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 5ul per test per one 10^6 cells in 0.1ml or 5ul per 100ul of whole blood, Immunofluorescence: 1:50-1:100
Host
Mouse
Reactivity
Human
Immunogen
Nuclear extract of human HL-60 cells was used as the immunogen for this Ku70 + Ku80 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
KU729
Applications
FACS, IF
Purity
Protein G affinity chromatography
Format
CF488 Conjugate
Buffer
500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Ku70 + Ku80 antibody at 2-8oC, protected from light.
Limitations
This Ku70 + Ku80 antibody is available for research use only.
Storage Conditions
Store the Ku70 + Ku80 antibody at 2-8°C, protected from light.
Formulation
500 ul at 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Ku70 + Ku80 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
FACS testing of permeabilized human 293T cells with Ku70 + Ku80 antibody. Black=cells alone; Gray=isotype control; Green= Ku70 + Ku80 antibody.
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