Chromogranin A Antibody Cocktail
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.1-0.2 µg/mL for 30 min at RT
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Human pheochromocytoma cells (LK2H10 + PHE5) and recombinant human Chromogranin A protein (CGA414) were used as the immunogen for this antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
LK2H10 + PHE5 + CGA414
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the Chromogranin A antibody cocktail at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Chromogranin A antibody is available for research use only.
Storage Conditions
Store the Chromogranin A antibody cocktail at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Finely granular cytoplasmic
Image Legend
IHC testing of human small cell lung carcinoma stained with chromogranin A antibody cocktail (clones LK2H10 + PHE5 + CGA414) .
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