CD74 Antibody
CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. CD74 antibody stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. antibody to CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+) .
Product Specifications
CAS Number
9007-83-4
Specifications
Host
Mouse
Reactivity
Human, Mouse
Immunogen
SU-DHL-4 lymphoma cells were used as the immunogen for this CD74 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
LN-2
Applications
FACS, IF, IHC-P, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the CD74 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD74 antibody is available for research use only.
Storage Conditions
Store the CD74 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Cell surface and paranuclear globular
Image Legend
Immunofluorescent staining of human Raji cells with CD74 antibody (clone LN-2, green) and Reddot nuclear stain (red) .
Documents
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Cole-Parmer SH-200D-G Mini Gyro Rocking Shaker; 230 VAC
(6alpha,11beta) -21- (3-Carboxy-1-oxopropoxy) -11,17-dihydroxy-6-methyl-Pregna-1,4-diene-3,20-dione monosodium salt
Lentiviral human AUTS2 sgRNA gene knockout kit - Lentiviral human AUTS2 sgRNA gene knockout kit (100)
Recombinant Xanthomonas campestris pv. vesicatoria UPF0060 membrane protein XCV3198 (XCV3198)