CD2 Antibody
CD2 interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate cell adhesion. CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on peripheral blood T lymphocytes, NK cells and thymocytes. CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. Interaction between CD2 and its counter receptor LFA3 (CD58) on opposing cells optimizes immune system recognition, thereby facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-3 µg/mL
Host
Mouse
Reactivity
Human
Immunogen
Human CD2 protein was used as the immunogen of the CD2 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
BH1
Applications
FACS, IF
Purity
Protein G affinity chromatography
Format
CF488 Conjugate
Buffer
500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the CD2 antibody at 2-8oC, protected from light.
Limitations
This CD2 antibody is available for research use only.
Storage Conditions
Store the CD2 antibody at 2-8°C, protected from light.
Formulation
500 ul at 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the CD2 antibody should be determined by the researcher.
Image Legend
Flow cytometry testing of human MOLT-4 cells with unlabeled CD2 antibody (clone BH1) ; Red=isotype control, Blue= CD2 antibody.
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