Interleukin-1 Receptor Antagonist Antibody / IL1RA / IL1RN

The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Product Specifications

CAS Number

9007-83-4

Specifications

ELISA (Capture) : 1-5 µg/mL

UniProt

P25086

Host

Mouse

Reactivity

Rat

Immunogen

An E. coli-derived rat protein (amino acids H27-Q178) was used as the immunogen for the Interleukin-1 Receptor Antagonist antibody.

Clonality

Monoclonal

Isotype

IgG2b

Clone

12C13

Applications

ELISA (Capture)

Purity

Affinity purified

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2% Trehalose

Reconstitution

After reconstitution, the Interleukin-1 Receptor Antagonist antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This Interleukin-1 Receptor Antagonist antibody is available for research use only.

Storage Conditions

After reconstitution, the Interleukin-1 Receptor Antagonist antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.