ABIN-1 Antibody / TNIP1

TNFAIP3-interacting protein 1, also called ABIN-1 or A20-binding inhibitor of NF-kappa-B activation 1, is a protein that in humans is encoded by the TNIP1 gene. This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene.