LXR beta Antibody / NR1H2
Liver X receptor beta (LXR-b) is a member of the nuclear receptor family of transcription factors. LXR-b is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2) . The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Flow cytometry: 1-3ug/million cells, Immunofluorescence: 5 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P55055
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A human recombinant partial protein (amino acids K31-A342) was used as the immunogen for the LXR beta antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, IF, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.0125% sodium azide
Reconstitution
Limitations
This LXR beta antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the LXR beta antibody should be determined by the researcher.
Location
Nuclear
Image Legend
Frequently Asked Questions
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