SHISA7 Antibody
Shisa7, a single-passing transmembrane protein, localizes at GABAergic inhibitory synapses and interacts with GABA-A receptors. Shisa7 controlled receptor abundance at synapses and sped up the channel deactivation kinetics. Shisa7 also potently enhanced the action of diazepam, a classic benzodiazepine, on GABA-A receptors. Genetic deletion of Shisa7 selectively impaired GABAergic transmission and diminished the effects of diazepam in mic
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
A6NL88
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A human recombinant partial protein (amino acids Y308-E535) was used as the immunogen for the SHISA7 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
Limitations
This SHISA7 antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the SHISA7 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) mouse brain and 2) rat brain with SHISA7 antibody. Predicted molecular weight ~70 kDa.
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