SOS1/EGFR-IN-2

SOS1/EGFR-IN-2 (Compound 4) is a SOS1 and EGFR dual inhibitor with IC50s of 8.3 and 14.6 nM, respectively. SOS1/EGFR-IN-2 exhibits significant antiproliferative effect on the cancer cells haboring various KRAS mutants[1].

Product Specifications

UNSPSC

12352211

Target

EGFR; SOS1

Type

Reference compound

Related Pathways

JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sos1-egfr-in-2.html

Smiles

C[C@@H](NC1=C2C(C=C(OC)C(OCCCN3CCOCC3)=C2)=NC=N1)C4=CC=CC(C(F)(F)F)=C4

Molecular Formula

C25H29F3N4O3

Molecular Weight

490.52

References & Citations

[1]Zeng Y, et al. Design, synthesis, and evaluation of dual son of sevenless 1 (SOS1) and epidermal growth factor receptor (EGFR) inhibitors for the treatment of cancers. Bioorg Chem. 2024 Sep 27;153:107833.