SOS1/EGFR-IN-2
SOS1/EGFR-IN-2 (Compound 4) is a SOS1 and EGFR dual inhibitor with IC50s of 8.3 and 14.6 nM, respectively. SOS1/EGFR-IN-2 exhibits significant antiproliferative effect on the cancer cells haboring various KRAS mutants[1].
Product Specifications
UNSPSC
12352211
Target
EGFR; SOS1
Type
Reference compound
Related Pathways
JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sos1-egfr-in-2.html
Smiles
C[C@@H](NC1=C2C(C=C(OC)C(OCCCN3CCOCC3)=C2)=NC=N1)C4=CC=CC(C(F)(F)F)=C4
Molecular Formula
C25H29F3N4O3
Molecular Weight
490.52
References & Citations
[1]Zeng Y, et al. Design, synthesis, and evaluation of dual son of sevenless 1 (SOS1) and epidermal growth factor receptor (EGFR) inhibitors for the treatment of cancers. Bioorg Chem. 2024 Sep 27;153:107833.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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