CYP2C19 Antibody
Cytochrome P450 2C19 (abbreviated CYP2C19) encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry: 1-2 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
P33261
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids QNQQSEFTIENLVITAADLLGAGTETT from the human protein were used as the immunogen for the CYP2C19 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
10G5
Applications
WB, IHC-P, FACS
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
Limitations
This CYP2C19 antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CYP2C19 antibody should be determined by the researcher.
Image Legend
IHC staining of FFPE human liver cancer with CYP2C19 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
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