SIRT1 Antibody / Sirtuin 1
Sirtuin 1, also known as SIR2L1 or SIRT1, is a protein that in humans is encoded by the SIRT1 gene. It is mapped to 10q21.3. Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity. Furthermore, Sirtuin 1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.25-0.5 µg/mL, Immunofluorescence: 5 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q96EB6
Host
Rabbit
Reactivity
Human
Immunogen
A human recombinant protein (amino acids Y142-H533) was used as the immunogen for the SIRT1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IF, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
Limitations
This SIRT1 antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the SIRT1 antibody should be determined by the researcher.
Location
Nuclear, cytoplasmic
Image Legend
Frequently Asked Questions
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