BAK1 Antibody
BAK, officially called Bcl2 antagonist killer, is a protein that in humans, encoded by the BAK gene. The BAK protein is a pro-apoptotic member of the Bcl-2 gene family which is involved in initiating apoptosis. BAK gene spans 7.6 kb and contains 6 exons. By Southern blot analysis of genomic DNA from human/rodent somatic cell hybrids, BAK gene is localized to chromosome 6. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Product Specifications
UniProt
Q16611
Host
Mouse
Immunogen
A human recombinant protein (amino acids A22-S211) was used as the immunogen for the BAK1 antibody.
Clonality
Monoclonal
Isotype
IgG2b
Applications
WB, IHC-P, ICC/IF, FACS
Format
Antigen affinity purified
Buffer
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Reconstitution
Limitations
This BAK1 antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6692050/datasheet/rq5500.pdf
CAS Number
9007-83-4
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