NQO1 Antibody
This gene is a member of the NAD (P) H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD) . Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [RefSeq]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:1000-1:5000, Immunofluorescence: 1:50-1:200, Immunohistochemistry (FFPE) : 1:50-1:200
UniProt
P15559
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide specific to human NQO1 was used as the immunogen for the NQO1 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
AAOB-14
Type
Recombinant
Applications
WB, IF, IHC-P
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the NQO1 antibody at -20oC.
Limitations
This NQO1 antibody is available for research use only.
Storage Conditions
Store the NQO1 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the NQO1 antibody should be determined by the researcher.
Image Legend
Western blot testing of human SH-SY5Y cell lysate with NQO1 antibody. Predicted molecular weight ~30 kDa.
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