ALAS1 Antibody / 5'-Aminolevulinate synthase 1
The ALAS1 gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate.
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000, Immunofluorescence/Immunocytochemistry: 1:50-1:200
UniProt
P13196
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human ALAS1 was used as the immunogen for the ALAS1 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
EOA-1
Type
Recombinant
Applications
IF/ICC, WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the ALAS1 antibody at -20oC.
Limitations
This ALAS1 antibody is available for research use only.
Storage Conditions
Store the ALAS1 antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the ALAS1 antibody should be determined by the researcher.
Image Legend
Western blot testing of human HepG2 cell lysate with ALAS1 antibody. Predicted molecular weight ~71 kDa.
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